Posebnu pažnju treba obratiti na moguće interakcije drugih lekova sa diazepamom, kod starijih pacijenata.
Inhibitori enzima CYP3A4 i/ili CYP2C19 dovode do povećanja koncentracije diazepama, dok lekovi koji indukuju ove enzime kao što su rifampicin, kantarion i pojedini antiepileptici mogu značajno sniziti koncentracije diazepama u plazmi.
Animal Knowledge Diazepam has long been demonstrated being teratogenic in mice and hamsters when presented orally at every day doses of 100 mg/kg or bigger (about 8 occasions the maximum recommended human dose [MRHD=one mg/kg/working day] or better over a mg/m2 basis). Cleft palate and encephalopathy are the most typical and continuously claimed malformations developed in these species by administration of superior, maternally harmful doses of diazepam all through organogenesis.
Istovremena primena ovih lekova može pojačati kliničke efekte diazepama, uključujući duboku sedaciju, klinički značajnu respiratornu i/ili kardiovaskularnu depresiju.
This medication must also have a Medication Information. Study and stick to these Directions cautiously. Read it yet again each time you refill your prescription in the event that There may be new details. Ask your health practitioner In case you have any questions.
Folks suffering with myasthenia gravis, a condition characterized by aberrant muscular weakness.
Your system processes this drug a lot more slowly but surely. Your click here health care provider may commence you on the lessen dosage so that a lot of of the drug doesn’t Make up in Your whole body. A lot of of the drug in One's body is usually harmful.
Your son or daughter’s health practitioner will start your son or daughter at the bottom dosage and improve it as wanted dependant on how they’re responding to and tolerating this medication.
Smanjenje ili povećanje koncentracije fenitoina u serumu. Neophodno je pažljivo pratiti koncentracije fenitoina pri uvođenju ili obustavi diazepama.
These anti-panic drugs are supposed for oral use. The tablets really should be taken whole and using a glass of drinking water. This signifies which the medication should not be taken by chewing or crushing the tablets.
When you’re using diazepam as an increase-on therapy for dealing with seizures, you might need a higher dosage within your other seizure medications.
If a nursing mother is really an extremely-rapid metabolizer of codeine, it could lead click here to the morphine overdose inside the nursing newborn and induce very critical Unintended effects.
Protracted withdrawal symptoms could final months to over twelve months. Consequently, there might be issues in differentiating withdrawal indications from probable re-emergence or continuation of signs and symptoms for which the benzodiazepine was getting used; having said that, small tolerance develops towards the amnestic reactions and other cognitive impairments due to benzodiazepines.
Your child’s health care provider will start your son or daughter at the lowest dosage and maximize it as desired based upon how they’re responding to and tolerating this medication.