Kada se koriste benzodiazepini dugog dejstva, važno je upozoriti da se ne prelazi na primenu benzodiazepina kratkog dejstva, jer mogu da se razviju simptomi obustave.
Fenobarbital uzet istovremeno može dovesti do aditivnog efekta na CNS. Povećan je rizik od sedacije i respiratorne depresije. Poznato je da fenobarbital indukuje CYP3A4 enzim i ubrzava metabolizam diazepama u jetri, što smanjuje efekat diazepama.
Benzodiazepine ne davati deci bez prethodne pažljive procene; dužina lečenja se mora svesti na bare minimum. Bezbednost i efikasnost primene diazepama kod dece mlađe od 6 meseci nije dokazana.
Istovremena primena ovih lekova može pojačati kliničke efekte diazepama, uključujući duboku sedaciju, klinički značajnu respiratornu i/ili kardiovaskularnu depresiju.
Experiments in Ladies breastfeeding have shown harmful toddler effects. An alternative to this medication need to be prescribed or you must cease breastfeeding whilst employing this medication.
The speed of transplacental passage of diazepam was researched in 33 situations of cephalic presentation wherever operative forceps delivery was indicated by intrauterine hypoxia or by extended second stage of labor.
Applying this medication with any of the next may perhaps result in an elevated danger of specified Negative effects but may very well be unavoidable sometimes. If used alongside one another, your health practitioner might change the dose or how frequently you use this click here medicine, or Present you with special Guidelines about the use of meals, alcohol, or tobacco.
Persons suffering from sleep apnoea syndrome, a condition during which breathing pauses for quick intervals throughout sleep.
Suicidal thoughts or actions is usually due to issues besides medicines. In case you have suicidal feelings or actions, your Health care supplier may well look for other causes.
Itrakonazol, ketokonazol i u manjoj meri flukonazol i vorikonazol su snažni inhibitori izoenzima CYP3A4 citohroma P450 i mogu povećati koncentraciju benzodiazepina u plazmi.
Antacids Diazepam peak concentrations are thirty% reduce when antacids are administered concurrently. Nevertheless, there isn't a effect on the extent of absorption.
Pediatric Use Protection and efficiency in pediatric people beneath the age of 6 months haven't been proven.
In addition, you should not generate, work machinery, or do other jobs that involve alertness until you understand how this drug affects you.
These drugs help website it become tougher for the human body to absorb diazepam. If you take them together, you might not get the total dose of diazepam, and it might not work likewise. These medicines consist of: